Methylglyoxal interaction with superoxide dismutase 1

Superoxide dismutase Superoxide dismutase

Superoxide Dismutase 1 and Cataract

"Pro captu lectoris habent sua fata libelli" (" According to the capabilities of the reader, books have their destiny ") Terentianus Maurus, 2 nd century roman grammarian

Human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS).

Copper chaperone for superoxide dismutase 1 (SOD1), CCS, is the physiological partner for the complex mechanism of SOD1 maturation. We report an in vitro model for human CCS-dependent SOD1 maturation based on the study of the interactions of human SOD1 (hSOD1) with full-length WT human CCS (hCCS), as well as with hCCS mutants and various truncated constructs comprising one or two of the protein...

Relationship between superoxide dismutase 1 and patients with Alzheimer’s disease

Aims: The purpose of this study was to investigate the association between superoxide dismutase 1 (SOD1) rs2070424, rs4998557 polymorphisms and the susceptibility of Alzheimer’s Disease (AD) in Chinese Han population. Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine genotypes of SOD1 polymorphisms in 98 patients with AD and 105 healthy...

Corneal endothelial integrity in aging mice lacking superoxide dismutase-1 and/or superoxide dismutase-3

PURPOSE To evaluate the age-induced changes in corneal endothelial morphology in mice lacking the cytosolic copper-zinc superoxide dismutase (SOD-1), the interstitial extracellular superoxide dismutase (SOD-3), or both of these SOD isoenzymes. METHODS The central corneal endothelial morphologies of old C57BL-6J wild type (n=19), SOD-1 null (n=16), SOD-3 null (n=15), and SOD1/3 null (n=11) mic...